Abstract

Porous carbons can be used for the purification of various bio-fluids , including the cleansing blood of inflammatory mediators in conditions such as sepsis or auto-immune diseases. Here we show that the control of pore size in carbons is a key factor to achieving efficient removal of cytokines. In particular, the surface area accessible by the protein governs the rate and effectiveness of the adsorption process. We demonstrate that novel mesoporous carbon synthesized from ternary MAX-phase carbides can be optimized for efficient adsorption of large inflammatory proteins. The synthesized carbons, having tunable pore size with a large volume of slit-shaped mesopores, outperformed all other materials or method in terms of efficiency of TFN - a removal and the results are comparable only with highly specific antibody-antigen interactions.

Introduction.

Activated carbons (AC), known for over 3000 years, still remain the most powerful conventional adsorbents, mainly due to their highly developed porous structure and these experiments carbide derived carbons (CDCs) outperformed any other materials or method for the efficient removal of TFN - a and the results are comparable only to highly specific antibody-antigen interactions.

Adsorption of the smaller cytokine IL-6 by most of the studied carbons was noticeably higher, but demonstrated similar trends. Strictly microporous Adsorba 300^o C was clearly inefficient. However, CDCs prepared at 600 ^o C having a limited amount of mesopores (pores 2-50 nm), adsorbed 66-77 % of the cytokines initially present in the solution for 1 hr. The CDCs produced at 1200 ^oC demonstrated 97-98.5 % adsorption which is comparable with the CXV samples, capable of adsorbing ~99% . The CDCs prepared from Ti₂AlC at 800 ^o C having the most developed mesoporosity decreased IL-6 concentration by ~99.8 %; the remaining IL-6 was close to the detection limit of ELISA used.

Lesson 2

Part 1

<== попередня сторінка	\|	наступна сторінка ==>
Organic compounds of carbon	\|	Practice

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