Deficiency diseases

In the rats deficiency of tocopherols results in damage of the reproductive system in males and females. Germinal epithelium is permanently damaged. Even if pregnancy occurs it results in death of the fetus and the fetus resorption occurs. In human subjects, however, no such relationship of vitamin E with reproductive system has been decidedly proved. Attempts to establish relation of vitamin E with reproductive physiology has given doubtful results in human subjects. In the nutrition charts, however, daily intake of vitamin E is recommended.

Vitamin E maintains the structural integrity of the muscles and peripheral vascular system in the animals. Consequently deficiency of this vitamin leads to dystrophy of such tissues.

In rabbits nucleic acid biosynthesis has been reported to be reduced in vitamin E deficiency. Most probably incorporation of the purine nucleotides in the biogenesis of nucleic acids is inhibited. Thus, alienation excretion is increased and the tissue nucleic acid content is lowered.

Involvement of vitamin E in biological oxidation has also been reported. Most probably, it is involved between cytochrome b and c. Vitamin E is an antioxidant. On account of this property it is believed to protect the cell membranes and prevent oxidation of unsaturated fatty acids forming integral part of the membrane lipids. Besides these, deficiency of this vitamin in the animals may cause hemolysis. The rate of lipogenesis is also decreased, the membranes of cells loose integrity and the rate of biological oxidation is also decreased.

Requirement The daily requirement of vitamin E of the adults has been recommended between 10-30 mg.

<== попередня сторінка	\|	наступна сторінка ==>
FAT SOLUBLE VITAMINS	\|	Vitamin K

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