Conjugated proteins metabolism
The biosynthesis of heme
The biosynthesis of heme occurs in marrow. There are some stages of this process:
1-st one:
Glycine+succinylCoAà delta-aminolevulinic acid+CO2+HSCoA (in this reaction the specific B6-dependent decarboxylase participates)
2-nd one:
2 delta-aminolevulinic acidàPorphobilinogen (PBG)
3-rd one: 4PBG à Protoporphyrin IX
4-th one: Protoporphyrin IX + Fe à Heme
4 Hemes + Globin (2alfa + 2 beta chains)à Hemoglobin
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