The physiological and pathological derivatives of hemoglobin and their spectra of taking up

There are next physiological derivatives of hemoglobin: HbO2 (oxyhemoglobin) and HbCO2 (carbhemoglobin). Oxyhemoglobin has 2 dark lines in yellow-green part of spectrum. HbCO2 hasn’t got own spectrum because CO2 joins to globin of hb. Its spectrum is 1 line in yellow-green part of spectrum (as in Hb).

There are next pathological derivatives of Hb: HbCO (carboxyhemoglobin), methoxyhemoglobin (MtHb), glycosylated hemoglobin (Hb_Glc)

HbCO is formed under influence of CO. Its spectrum is 2 dark lines in yellow-green part of sun spectrum, but in comparison with HbO2 this hemoglobin isn’t reduced under influence of Stock’s reagent.

Methoxyhemoglobin is formed under action of oxidants. The 3-rd valency in iron of heme appears to which the OH group joins.its spectrum is 3 dark lines: 2 of them are in yellow-green part of sun spectrum and 1 line in red part of sun spectrum.

Glycosylated hemoglobin is formed due to binding of glucose to beta-chains of Hb. Formation of this hemoglobin occurs in long time hyperglycemia (more than 2-3 months), e.g in diabetes mellitus.

The pathological derivatives of hemoglobin are dangerous because they don’t function as transporters of oxygen and carbon dioxide.

<== попередня сторінка	\|	наступна сторінка ==>
Metabolism in erythrocytes	\|	Biochemistry of white blood cells

Не знайшли потрібну інформацію? Скористайтесь пошуком google:

Генерація сторінки за: 0.004 сек.