Beta-oxidation of FFA and its energetic value

FFA is activated in cytosol, yielding active fatty acid, or acylCoA. acylCoA enters the mitochondrions with carnitine. acylCoA is oxidized under action of FP(FAD), dehydroacylCoA is formed. It is hydrated to beta-hydroxyacylCoA. It is oxidized to beta-ketoacylCoA under action of NAD. ketoacylCoA is thiolyzed to a new acylCoA and acetylCoA.

New acylCoA enters the new cycle of beta-oxidation (in 2-nd reaction) again until Butyric acid formation. This acid undergoes the 1-st cycle of beta-oxidation and gives 2 AcetylCoA. Thus, the principle of beta-oxidation consists in active fatty acid is decreased on 2 Carbon atoms (in the kind of AcetylCoA) during 1-st cycle and 1NADH2, 1FPH2 are also formed. The number of cycles can be calculated on next formula: N= n(C)/2 – 1.

The quantity of AcetylCoA can be calculated on next formula: N= n(C)/2.

Thus, C15H31COOH gives C16/2 – 1= 7cycles; C16/2=8 AcetylCoA.

Each AcetylCoA gives 12ATP, therefore 8 AcetylCoA give 8x12=96ATP. 1 cycle gives 1FPH2 and 1NADH2, therefore 7 cycles give 7x2=14ATP; 7NADH2 give 7x3=21ATP. All together will be 14+21=35ATP: 35+96=131ATP. 1 ATP is used in 1-st reaction (activation of FFA). Therefore energetical balance (value) of beta-oxidation of 1 molecule of C15H31COOH is equal 131-1=130ATP.

Lipids peroxidation (LPO) and its role

<== попередня сторінка	\|	наступна сторінка ==>
The conversion of Glycerol and FFA: formation of Triacylglycerols (TAG) and Phospholipids (PhL)	\|	Polyunsaturated fatty acids (PUFA) undergo the LPO. Initiators of LPO are active forms of oxygen (AFO) (see the theme “The types of oxidation in section Bioenergetics”).

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