II. Read the following text paying attention to the highlighted words. Explain or interpret the contextual meaning of the underlined phrases

Viruses occupy a special taxonomic position: they are not plants, animals, or prokaryotic bacteria, and they are generally placed in their own kingdom or imperia. In fact, viruses should not even be considered organisms, in the strictest sense, because they are not free-living (i.e., they cannot reproduce and carry on metabolic processes without a host cell).

All true viruses contain nucleic acid, either DNA or RNA, and protein. The nucleic acid encodes the genetic information unique for each virus. The infective, extracellular (outside the cell) form of a virus is called the virion. It contains at least one unique protein synthesized by specific genes in the nucleic acid of that virus. In virtually all viruses, at least one of these proteins forms a shell (called a capsid) around the nucleic acid. Certain viruses also have other proteins internal to the capsid; some of these proteins act as enzymes, often during the synthesis of viral nucleic acids. Viroids (meaning “viruslike”) are disease-causing organisms that contain only nucleic acid and have no structural proteins. Other viruslike particles called prions are composed primarily of a protein tightly complexed with a small nucleic acid molecule. Prions are very resistant to inactivation and appear to cause degenerated brain disease in mammals, including humans.

Viruses are quintessential parasites; they depend on the host cell for almost all of their life-sustaining functions. Unlike true organisms, viruses cannot synthesize proteins, because they lack ribosomes for the translation of viral messenger RNA into proteins. Viruses must use the ribosomes of their host cells to translate viral mRNA into viral proteins.

Viruses are also energy parasites; unlike cells, they cannot generate or store energy in the form of adenosine triphosphate (ATP). The virus derives energy, and all other metabolic functions, from the host cell. The invading virus uses the nucleotides and amino acids of the host cell to synthesize its nucleic acids and proteins, respectively. Some viruses use the lipids and sugar chains of the host cell to form their membranes and glycoproteins.

The true infectious part of any virus is its nucleic acid, either DNA or RNA but never both. In many viruses, but not all, the nucleic acid alone, stripped of its protein coat (capsid), can infect (transfect) cells, although considerably less efficiently than can the intact virions.

The virion capsid has three functions: (1) to protect the viral nucleic acid from digestion by certain enzymes (nucleases), (2) to furnish sites on its surface that recognize and attach (adsorb) the virion to receptors on the surface of the host cell, and (3), in some viruses, to provide proteins that form part of a specialized component which enables the virion to penetrate through the cell surface membrane or, in special cases, to inject the infectious nucleic acid into the interior of the host cell.

Biologistsuse several criteria to classify viruses, includingtheir nucleic acid content, their size, the shape of their protein capsid, the presence of a surrounding lipoprotein envelope, as well as the types and range of organisms the viruses infect, and the disease they cause.

The primary taxonomic division is into two classes based on nucleic acid content: DNA viruses or RNA viruses. Both the DNA and the RNA viruses are subdivided into those that contain either double-stranded or single-stranded DNA or RNA. Further subdivision of the RNA viruses is based on whether the RNA genome is segmented or not. Viruses can “evolve” in the sense that their DNA and RNA sequence changes rapidly. This is because viruses replicate very often and cannot “repair” errors in the sequences, as cells can. The changeable nature of viruses is the reason why vaccines for many diseases like the common cold cannot be developed.

Viruses can exist outside cells but they must enter cells to reproduce. Here, they commandeer the DNA replication and protein synthesis machinery of the host (the nucleus, ribosomes, and ER) and use it to produce the progeny viruses, which may busrt from the cell causing its death. Certain viruses, particularly bacteriophages, are called temperate because the infection does not immediately result in cell death. The viral genetic material remains dormant or is actually integrated into the genome of the host cell. Cells infected with temperate viruses are called lysogenic because the cells tend to be broken down when they encounter some chemical or physical factor, such as ultraviolet light. In addition, many animal and plant viruses, the genetic information of which is not integrated into the host DNA, may lie dormant in tissues for long periods of time without causing much, if any, tissue damage. Viral infection does not always result in cell death or tissue injury; in fact, most viruses lie dormant in tissue without ever causing pathological effects, or they do so only under other, often environmental, provocations.

Although viruses were originally discovered and characterized on the basis of the diseases they cause, most viruses that infect bacteria, plants, and animals (including humans) do not cause disease. In fact, bacteriophages may be helpful in that they rapidly transfer genetic information from one bacterium to another, and viruses of plants and animals may convey genetic information among similar species, helping their hosts survive in hostile environments. In the future this could also be true for humans. Recombinant DNA biotechnology shows great promise for the repair of genetic defects. Afflicted persons are injected with cells transformed by viruses that carry a functional copy of the defective human gene. The virus integrates the normal gene into the DNA of the human cell.

Of those viruses that cause disease, some cause short-term (acute) diseases and others recurring or long-term (chronic) diseases. Some viruses cause acute disease from which there is fairly rapid recovery but may persist in the tissues, remaining dormant for long periods of time, and then become active again, bringing about serious disease decades later. Slowly progressive viruses have long incubation periods before the onset of disease. The DNA of certain viruses becomes integrated into the genome of the host cell, often resulting in malignant transformation of cells, which become cancers.

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I. Match each word on the left to its correct definition on the right	\|	Vocabulary notes

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